Calcium and ROS: A mutual interplay

AbstractCalcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca2+ signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules involved in various cellular processes including growth and cell death. Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks. However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders

WS-BPEL extension for compliance fragments (BPEL4CFrags), Version 1.0

The Web Services Business Process Execution Language, version 2.0 (WS-BPEL 2.0 or BPEL for brevity) introduces a model for business processes based on Web services. A BPEL process orchestrates interactions among different Web services. The language comprises features required to describe complex control flows, including error handling and compensation behaviour. BPEL for Compliance Fragments (BPEL4CFrags) enables the specification of compliance fragments providing a reusable solution for implementing and meeting compliance requirements. The compliance fragments are not necessarily executable. Providing process modeling support at design time requires the completion of not directly executable compliance fragments, because compliance fragments contain several degrees of freedom, into already existing executable BPEL processes. Moreover, assistance for creation of executable BPEL processes from scratch during IT refinement has to be provided

A Classification of BPEL Extensions

The Business Process Execution Language (BPEL) has emerged as de-facto standard for business processes implementation. This language is designed to be extensible for including additional valuable features in a standardized manner. There are a number of BPEL extensions available. They are, however, neither classified nor evaluated with respect to their compliance to the BPEL standard. This article fills this gap by providing a framework for classifying BPEL extensions, a classification of existing extensions, and a guideline for designing BPEL extensions